Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004685)
Formula
SVG example
11-oxidation
Reactant Methylprednisolone Product Methylprednisolone M1 Metabolite
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info
Metabolic Type Oxidation - 11-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004689 Methylprednisolone Methylprednisolone M13 Metabolite Oxidation - 22-hydroxylation Methylprednisolone [1]
MR004692 Methylprednisolone Methylprednisolone M2 Metabolite Unclear Methylprednisolone [1]
MR004682 Methylprednisolone Methylprednisolone M4 Metabolite Oxidation - 6,7-dehydrogenation Methylprednisolone [1]
MR004679 Methylprednisolone Methylprednisolone M7 Metabolite Oxidation - 6-hydroxylation Methylprednisolone [1]
MR004693 Methylprednisolone Methylprednisolone M3 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004686 Methylprednisolone M1 Metabolite Methylprednisolone M11 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004688 Methylprednisolone M1 Metabolite Methylprednisolone M8 Metabolite Oxidation - 16-hydroxylation Methylprednisolone [1]
MR004687 Methylprednisolone M1 Metabolite Methylprednisolone M12 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
References
1 Urinary profile of methylprednisolone and its metabolites after oral and topical administrations
2 Carbonyl reduction pathways in drug metabolism

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