Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004726)
Formula
SVG example
Reduction
Reactant Metronidazole Product Acetamide
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004729 Metronidazole 1-acetic acid-2-methyl Oxidation - Oxidationn Metronidazole [1], [2]
MR004732 Metronidazole 2-carboxylic Oxidation - Oxidationn Metronidazole [2]
MR004728 Metronidazole 2-hydroxymethyl Oxidation - Oxidationn Metronidazole [2]
MR004727 Metronidazole 2-hydroxymetronidazole Oxidation - Hydrolyzationn Metronidazole [3], [1], [4], [2]
MR004734 Metronidazole 5-amino Reduction - Reduction Metronidazole [2]
MR004730 Metronidazole Metronidazole Metabolite XI Oxidation - Oxidationn Metronidazole [2]
MR004731 Metronidazole Metronidazole Metabolite XII Oxidation - Oxidationn Metronidazole [2]
MR004733 Metronidazole Metronidazole Metabolite XIII Oxidation - Oxidationn Metronidazole [2]
MR004725 Metronidazole N-(2-hydroxyethyl)-oxamic acid Reduction - Reduction Metronidazole [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013803 Acetohydroxamic Acid Acetamide Unclear - Unclear Acetohydroxamic Acid [5]
References
1 Disposition and metabolism of metronidazole in patients with liver failure
2 Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms
3 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
4 Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation
5 Disposition of 14C-acetohydroxamic acid and 14C-acetamide in the rat

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