Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004728)
Formula Reactant Metronidazole Product 2-hydroxymethyl
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004729 Metronidazole 1-acetic acid-2-methyl Oxidation - Oxidationn Metronidazole [1], [2]
MR004732 Metronidazole 2-carboxylic Oxidation - Oxidationn Metronidazole [2]
MR004727 Metronidazole 2-hydroxymetronidazole Oxidation - Hydrolyzationn Metronidazole [3], [1], [4], [2]
MR004734 Metronidazole 5-amino Reduction - Reduction Metronidazole [2]
MR004726 Metronidazole Acetamide Reduction - Reduction Metronidazole [2]
MR004730 Metronidazole Metronidazole Metabolite XI Oxidation - Oxidationn Metronidazole [2]
MR004731 Metronidazole Metronidazole Metabolite XII Oxidation - Oxidationn Metronidazole [2]
MR004733 Metronidazole Metronidazole Metabolite XIII Oxidation - Oxidationn Metronidazole [2]
MR004725 Metronidazole N-(2-hydroxyethyl)-oxamic acid Reduction - Reduction Metronidazole [2]
References
1 Disposition and metabolism of metronidazole in patients with liver failure
2 Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms
3 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
4 Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation

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