General Information of This Metabolic Reaction (MR) (ID: MR004754)
Formula
SVG example
Reactant Midostaurin Metabolite P6 Product Midostaurin Metabolite P6B
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005729 Benzyl alcohol Benzoic Acid Oxidation - Oxidationn Benzyl alcohol [1], [2]
MR007541 Benzylamine Benzylamine M16 Unclear Benzylamine [3]
MR004753 Midostaurin Midostaurin Metabolite P6 Unclear Midostaurin [4]
MR004299 Naphthoquinone Benzoic acid Unclear Naphthoquinone [5]
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [6]
MR012043 Triamide Benzoic acid Unclear - Unclear Farglitazar [7]
MR003835 3-Phenylpropionic acid Benzoic acid Unclear BE-14348A [8]
MR012039 Farglitazar Metabolites M3 Benzoic acid Hydrolysis - Hydrolysis Farglitazar [7]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [9]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [9]
MR012038 Benzamide Benzoic acid Hydrolysis - Hydrolysis Farglitazar [7]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [10]
MR009198 3-(phenyl)acetic acid Benzoic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [11]
MR005288 Cinnamic acid Metabolite Benzoic acid Unclear Cinnamic acid [12]
MR004493 3-Hydroxybenzoic acid Benzoic acid Unclear VS-12343 [13]
MR004491 Phenylacetic acid Benzoic acid Unclear VS-12343 [13]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007542 Benzylamine M16 Benzylamine M12 Unclear Benzylamine [3]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010230 Isocarboxazid Hippuric acid Unclear - Unclear Isocarboxazid [14]
MR005014 4-Trifluoromethylphenol Hippuric acid Oxidation - O-dealkylation Fluoxetine hydrochloride [15]
MR000219 Benzoic acid Hippuric acid Conjugation - Glycine Conjugation Amphetamine [6]
MR006962 3-(Phenyl)propionic acid Hippuric acid Unclear CCG-208408 [16]
MR003837 Benzoic acid Hippuric acid Unclear BE-14348A [8]
MR006885 Phenylacetone Hippuric acid Unclear Lisdexamfetamine [10]
MR005290 Cinnamic acid Metabolite Hippuric acid Unclear Cinnamic acid [12]
MR009199 Benzoic acid Hippuric acid Conjugation - Glycination 3,4-Dihydroxycinnamic Acid [11]
MR013577 4'-hydroxybenzoic acid Hippuric acid Unclear Epigallocatechin gallate [17]
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References
1 Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304.
2 Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
3 Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates
4 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.
5 Identification of naphthalene metabolism by white rot fungus Pleurotus eryngii
6 DrugBank(Pharmacology-Metabolism)Amphetamine
7 The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms
8 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
9 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
10 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
11 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
12 Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
13 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
14 DrugBank(Pharmacology-Metabolism):Isocarboxazid
15 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride
16 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
17 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

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