General Information of This Metabolic Reaction (MR) (ID: MR013577)
Formula
SVG example
Reactant 4'-hydroxybenzoic acid Product Hippuric acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008831 Cetraxate PHBA Unclear - Unclear Cetraxate [1]
MR005873 Liquiritin metabolite M9 Liquiritin metabolite M11 Other reaction - Degradation Liquiritin [2]
MR006959 3-(4'-Hydroxyphenyl)acetic acid 4'-Hydroxybenzoic acid Unclear CCG-208408 [3]
MR013576 4'-hydroxyphenylacetic acid 4'-hydroxybenzoic acid Unclear Epigallocatechin gallate [4]
MR004502 4'-Hydroxyphenylacetic acid 4-Hydroxybenzoic acid Unclear VS-12343 [5]
MR004413 4-Hydroxy-4-(4-hydroxyphenyl) butanoic acid 4-Hydroxybenzoic acid Oxidation - Alkyl-chain hydroxylation N-nonylphenol [6]
MR004400 1-(4-hydroxyphenyl)ethanone 4-Hydroxybenzoic acid Unclear N-nonylphenol [6]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005874 Liquiritin metabolite M11 Liquiritin metabolite M13 Other reaction - Amino acid Liquiritin [2]
MR005875 Liquiritin metabolite M11 Liquiritin metabolite M14 Other reaction - Amino acid Liquiritin [2]
MR006960 4'-Hydroxybenzoic acid 4'-Hydroxyhippuric acid Unclear CCG-208408 [3]
MR014114 4-Hydroxybenzoic acid 3,4-Dihydroxybenzoic acid Oxidation - Alkyl-chain hydroxylation N-nonylphenol [6]
MR014115 4-Hydroxybenzoic acid 3,4-Dihydroxybenzoic acid Unclear N-nonylphenol [6]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010230 Isocarboxazid Hippuric acid Unclear - Unclear Isocarboxazid [7]
MR007547 Benzylamine M16 Benzylamine M1 Unclear Benzylamine [8]
MR004754 Midostaurin Metabolite P6 Midostaurin Metabolite P6B Unclear Midostaurin [9]
MR005014 4-Trifluoromethylphenol Hippuric acid Oxidation - O-dealkylation Fluoxetine hydrochloride [10]
MR000219 Benzoic acid Hippuric acid Conjugation - Glycine Conjugation Amphetamine [11]
MR006962 3-(Phenyl)propionic acid Hippuric acid Unclear CCG-208408 [3]
MR003837 Benzoic acid Hippuric acid Unclear BE-14348A [12]
MR006885 Phenylacetone Hippuric acid Unclear Lisdexamfetamine [13]
MR005290 Cinnamic acid Metabolite Hippuric acid Unclear Cinnamic acid [14]
MR009199 Benzoic acid Hippuric acid Conjugation - Glycination 3,4-Dihydroxycinnamic Acid [15]
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References
1 [Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent]
2 A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer
3 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
4 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement
7 DrugBank(Pharmacology-Metabolism):Isocarboxazid
8 Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates
9 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.
10 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride
11 DrugBank(Pharmacology-Metabolism)Amphetamine
12 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
13 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
14 Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
15 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota

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