Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004757)
Formula
SVG example
N-dealkylation
Reactant Mifepristone Product Monodemethylated mifepristone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004762 Mifepristone 17alpha-hydroxymifepristone Oxidation - Aliphatic hydroxylation Mifepristone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004758 Monodemethylated mifepristone Mifepristone Metabolite M2 Unclear Mifepristone [3]
MR004760 Monodemethylated mifepristone Mifepristone Metabolite M4 Unclear Mifepristone [3]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 PAT Program report: background and current status. Proficiency Analytical Testing
3 In vitro metabolism of mifepristone (RU-486) in rat, monkey and human hepatic S9 fractions: identification of three new mifepristone metabolites

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