Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004762)
Formula
SVG example
Aliphatic hydroxylation
Reactant Mifepristone Product 17alpha-hydroxymifepristone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004757 Mifepristone Monodemethylated mifepristone Oxidation - N-dealkylation Mifepristone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004763 17alpha-hydroxymifepristone Mifepristone Metabolite M4 Unclear Mifepristone [3]
MR004764 17alpha-hydroxymifepristone Mifepristone Metabolite M6 Unclear Mifepristone [3]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Respirator performance terminology
3 In vitro metabolism of mifepristone (RU-486) in rat, monkey and human hepatic S9 fractions: identification of three new mifepristone metabolites

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