Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004815)
Formula
UGT1A9 ...
SVG example
Glucuronidation
Reactant Mycophenolate mofetil Product Mycophenolic acid glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004820 Mycophenolate mofetil 7-O-glucoside Unclear Mycophenolate mofetil [1]
MR004821 Mycophenolate mofetil Acyl glucuronide Unclear Mycophenolate mofetil [1]
MR004811 Mycophenolate mofetil Mycophenolic acid Unclear Mycophenolate mofetil [2], [3], [4]
MR004816 Mycophenolate mofetil Mycophenolic acyl-glucuronide (AcMPAG) Conjugation - Glucuronidation Mycophenolate mofetil [4]
MR004817 Mycophenolate mofetil N-(2-carboxymethyl)-morpholine Hydrolysis - Hydrolyzation Mycophenolate mofetil [4]
MR004818 Mycophenolate mofetil N-(2-hydroxyethyl)-morpholine Unclear Mycophenolate mofetil [4]
MR004819 Mycophenolate mofetil N-(2-hydroxyethyl)-morpholine N-oxide Unclear Mycophenolate mofetil [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004824 Mycophenolic acid Mycophenolic acid glucuronide Conjugation - O-glucuronidation Mycophenolic acid [5], [6]
References
1 Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability
2 The emergence of mycophenolate mofetilin dermatology: from its roots in the world of organ transplantation to its versatile role in the dermatology treatment room
3 The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
4 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
5 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
6 The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

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