Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004846)
Formula Reactant 4-(6-Hydroxy-2-naphthyl)- butan-2-one Product 4-(6-Hydroxy-2-naphthyl)- butan-2-one glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004838 Nabumetone 4-(6-Hydroxy-2-naphthyl)- butan-2-one Oxidation - O-demethylation Nabumetone [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004839 4-(6-Hydroxy-2-naphthyl)- butan-2-one 4-(6-hydroxy-2-naphthyl)- butan-2-ol Reduction - Reduction Nabumetone [1]
MR004849 4-(6-Hydroxy-2-naphthyl)- butan-2-one 4-(6-Hydroxy-2-naphthyl)- butan-2-one sulfate Conjugation - Sulfonation Nabumetone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004847 4-(6-Hydroxy-2-naphthyl)- butan-2-one glucuronide 4-(6-Hydroxy-2-naphthyl)- butan-2-one glucuronide glycine conjugate Conjugation - Glycine conjugation Nabumetone [1]
References
1 Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?

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