Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004871)
Formula
CYP2C9 ...
SVG example
O-demethylation
Reactant Naproxen Product O-Desmethylnaproxen
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004861 Naproxen Naproxen metabolite M1 Oxidation - Hydrolyzationn Naproxen [1]
MR004875 Naproxen Naproxen O-glucuronide Conjugation - Glucuronidation Naproxen [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004873 O-Desmethylnaproxen O-Desmethylnaproxen acyl glucuronide Conjugation - Glucuronidation Naproxen [3]
MR004872 O-Desmethylnaproxen O-Desmethylnaproxen O-glucuronide Conjugation - Glucuronidation Naproxen [3]
MR004874 O-Desmethylnaproxen O-Desmethylnaproxen sulfate Conjugation - Sulfonation Naproxen [3]
References
1 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
2 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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