Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004875)
Formula
SVG example
Glucuronidation
Reactant Naproxen Product Naproxen O-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004861 Naproxen Naproxen metabolite M1 Oxidation - Hydrolyzationn Naproxen [1]
MR004871 Naproxen O-Desmethylnaproxen Oxidation - O-demethylation Naproxen [2], [3], [4], [5]
References
1 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8.
4 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
5 [Pharmacokinetics of phenazone after bilateral ovariectomy in female rabbits]

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.