Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004937)
Formula
SVG example
Hydrolyzationn
Reactant Thalidomide Product Cis, trans-5'-Hydroxythalidomide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004921 Thalidomide 2-phthalimidoglutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004943 Thalidomide 4-hydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [3]
MR004914 Thalidomide 4-phthalimidoglutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004934 Thalidomide 5-Hydroxythalidomide Oxidation - Aromatic hydroxylation Thalidomide [4], [2]
MR004925 Thalidomide Alpha-(o-carboxybenzamido)glutarimide Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004942 Thalidomide N-Hydroxythalidomide Oxidation - Hydrolyzation Thalidomide [3]
MR004939 Thalidomide Thalidomide arene oxide Oxidation - Epoxidation Thalidomide [4], [2]
MR004941 Thalidomide Thalidomide-5-O-glucuronide Oxidation - Hydrolyzationn Thalidomide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004938 Cis, trans-5'-Hydroxythalidomide Cis,trans-5,5'-dihydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [2]
References
1 Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
2 Thalidomide metabolism and hydrolysis: mechanisms and implications
3 Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients. J Biochem Mol Toxicol. 2000;14(3):140-7.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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