Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004938)
Formula Reactant Cis, trans-5'-Hydroxythalidomide Product Cis,trans-5,5'-dihydroxythalidomide
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004937 Thalidomide Cis, trans-5'-Hydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Thalidomide metabolism and hydrolysis: mechanisms and implications

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