Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005042)
Formula
SVG example
Reactant 4'-Hydroxyflurbiprofen Product 3',4'-dihydroxyflurbiprofen
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005041 Flurbiprofen sodium 4'-Hydroxyflurbiprofen Oxidation - 4'-hydroxylation Flurbiprofen sodium [1], [2]
MR011802 R-flurbiprofen 4'-hydroxyflurbiprofen Unclear - Unclear R-flurbiprofen [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005043 3',4'-dihydroxyflurbiprofen 3'-hydroxy-4'-methoxyflurbiprofen Unclear Flurbiprofen sodium [4]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes
3 Stereoselective disposition of flurbiprofen in normal volunteers
4 Disposition of flurbiprofen in man: influence of stereochemistry and age

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