| General Information of This Metabolic Reaction (MR) (ID:
MR005044) |
| Formula |
|
| Reactant |
Flurbiprofen sodium |
Product |
Flurbiprofen glucuronide |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
UDP-glucuronosyltransferase 2B7 (UGT2B7)
|
DME Info
|
|
UDP-glucuronosyltransferase 1A1 (UGT1A1)
|
DME Info
|
|
UDP-glucuronosyltransferase 1A3 (UGT1A3)
|
DME Info
|
|
UDP-glucuronosyltransferase 1A9 (UGT1A9)
|
DME Info
|
|
UDP-glucuronosyltransferase 2B4 (UGT2B4)
|
DME Info
|
|
Metabolic Type
|
Conjugation
-
Glucuronidation
|
|
|
|
|
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|
| Other MR(s) Related to The Reactant of This MR |
|
Other MR(s) That Metabolize The Reactant of This MR
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| References |
| 1 |
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
|
| 2 |
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes
|
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