Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005067)
Formula Reactant Guanfacine hydrochloride Product Guanfacine hydrochloride Metabolite M5
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005062 Guanfacine hydrochloride 3-hydroxyguanfacine Oxidation - Oxidationn Guanfacine hydrochloride [1], [2]
MR005065 Guanfacine hydrochloride Guanfacine dihydro-diol Multi-steps Reaction - Epoxidation; hydration Guanfacine hydrochloride [3]
MR005066 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M4 Conjugation - Glucuronidation Guanfacine hydrochloride [3]
MR005070 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M6 Oxidation - Oxidationn Guanfacine hydrochloride [3]
MR005068 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M7 Conjugation - Glucuronidation Guanfacine hydrochloride [3]
MR005069 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M8 Conjugation - Glucuronidation Guanfacine hydrochloride [3]
References
1 Determination of 3-hydroxy-guanfacine in biological fluids by electron-capture gas-liquid chromatography
2 Pharmacokinetics and metabolism of guanfacine in man: a review
3 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets

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