Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005062)
Formula
SVG example
Oxidationn
Reactant Guanfacine hydrochloride Product 3-hydroxyguanfacine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005065 Guanfacine hydrochloride Guanfacine dihydro-diol Multi-steps Reaction - Epoxidation; hydration Guanfacine hydrochloride [1]
MR005066 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M4 Conjugation - Glucuronidation Guanfacine hydrochloride [1]
MR005067 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M5 Conjugation - Glucuronidation Guanfacine hydrochloride [1]
MR005070 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M6 Oxidation - Oxidationn Guanfacine hydrochloride [1]
MR005068 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M7 Conjugation - Glucuronidation Guanfacine hydrochloride [1]
MR005069 Guanfacine hydrochloride Guanfacine hydrochloride Metabolite M8 Conjugation - Glucuronidation Guanfacine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010578 Guanfacine 3-Hydroxyguanfacine Oxidation - Oxidation Guanfacine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011444 3-hydroxyGuanfacine Glucuronide of hydroxy-Guanfacine Conjugation - Glucuronidation Guanfacine [1]
MR005064 3-hydroxyguanfacine Guanfacine 3-glucuronide Conjugation - O-glucuronidation Guanfacine hydrochloride [2]
MR005063 3-hydroxyguanfacine Guanfacine 3-sulfate Conjugation - Sulfation Guanfacine hydrochloride [2]
MR010579 3-Hydroxyguanfacine Guanfacine Metabolite M2 Conjugation - Glucuronidation Guanfacine [1]
MR010580 3-Hydroxyguanfacine Guanfacine Metabolite M3 Conjugation - Sulfation Guanfacine [1]
MR011445 3-hydroxyGuanfacine Sulfate of hydroxy-Guanfacine Conjugation - Sulfation Guanfacine [1]
⏷ Show the Full List of MR
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets
2 DrugBank(Pharmacology-Metabolism):Guanfacine hydrochloride

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