Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005120)
Formula
SVG example
O-glucuronidation
Reactant 6-alpha-hydromorphol Product 6-alpha-hydromorphol glucuronide conjugate 2
Reactant Info Product Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007115 Dihydrocodeine Dihydromorphine Oxidation - O-demethylation Dihydrocodeine [1], [2]
MR005118 6-alpha-hydrocodol 6-alpha-hydromorphol Oxidation - O-demethylation Hydrocodone bitartrate [3]
MR005110 Hydromorphone 6-alpha-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007116 Dihydromorphine DHM-glucuronides Conjugation - Glucuronidation Dihydrocodeine [1]
MR005119 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 1 Conjugation - O-glucuronidation Hydrocodone bitartrate [3]
References
1 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
2 Dihydrocodeine: safety concerns
3 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate

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