Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007115)
Formula
SVG example
O-demethylation
Reactant Dihydrocodeine Product Dihydromorphine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007119 Dihydrocodeine DHNC Oxidation - N-demethylation Dihydrocodeine [1], [2]
MR007117 Dihydrocodeine Dihydrocodeine-6-glucuronide Conjugation - Glucuronidation Dihydrocodeine [3], [2]
MR007121 Dihydrocodeine Nordihydrocodeine Unclear Dihydrocodeine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005118 6-alpha-hydrocodol 6-alpha-hydromorphol Oxidation - O-demethylation Hydrocodone bitartrate [4]
MR005110 Hydromorphone 6-alpha-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007116 Dihydromorphine DHM-glucuronides Conjugation - Glucuronidation Dihydrocodeine [3]
MR005119 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 1 Conjugation - O-glucuronidation Hydrocodone bitartrate [4]
MR005120 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 2 Conjugation - O-glucuronidation Hydrocodone bitartrate [4]
References
1 Metabolism and pharmacokinetics of dihydrocodeine in dog
2 Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharm Drug Dispos. 2019 Nov;40(9):350-357.
3 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
4 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate

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