Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005138)
Formula
UGT1A3 ...
SVG example
Glucuronidation
Reactant Hydromorphone Product Hydromorphone-3-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005137 Hydromorphone Norhydromorphone Oxidation - N-demethylation Hydromorphone [1]
MR005110 Hydromorphone 6-alpha-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [2]
MR011211 Hydromorphone Hydrocodone M462 Conjugation - Glucuronidation Hydrocodone [3]
MR011202 Hydromorphone Hydromorphol Reduction - Ketone reduction Hydrocodone [3]
MR005122 Hydromorphone Hydromorphone glucuronide conjugate Conjugation - O-glucuronidation Hydrocodone bitartrate [2]
MR005111 Hydromorphone 6-beta-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [2]
References
1 Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. Xenobiotica. 2004 Apr;34(4):335-44.;
2 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate
3 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.