Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011202)
Formula Reactant Hydromorphone Product Hydromorphol
Reactant Info Product Info
Metabolic Type Reduction - Ketone reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005138 Hydromorphone Hydromorphone-3-glucuronide Conjugation - Glucuronidation Hydromorphone [1], [2], [3]
MR005137 Hydromorphone Norhydromorphone Oxidation - N-demethylation Hydromorphone [4]
MR005110 Hydromorphone 6-alpha-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [5]
MR011211 Hydromorphone Hydrocodone M462 Conjugation - Glucuronidation Hydrocodone [6]
MR005122 Hydromorphone Hydromorphone glucuronide conjugate Conjugation - O-glucuronidation Hydrocodone bitartrate [5]
MR005111 Hydromorphone 6-beta-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011203 Hydromorphol Hydrocodone M274 Oxidation - N-demethylation Hydrocodone [6]
MR011208 Hydromorphol Hydrocodone M286 Multi-steps Reaction - Possible combination of hydroxylation; dehydration Hydrocodone [6]
MR011209 Hydromorphol Hydrocodone M464 Conjugation - Glucuronidation Hydrocodone [6]
References
1 Hydromorphone
2 Opioid pharmacokinetic drug-drug interactions. Am J Manag Care. 2011 Sep;17 Suppl 11:S276-87.
3 Opioid therapies and cytochrome p450 interactions. J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14.
4 Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. Xenobiotica. 2004 Apr;34(4):335-44.;
5 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate
6 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite

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