Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005146)
Formula
SVG example
Hydrolyzationn
Reactant Aniline Product 4-aminophenol
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012858 Aniline 2-aminophenol Unclear Aniline [1]
MR012853 Aniline Acetanilide-d5 Unclear Aniline [2]
MR012857 Aniline N-Hydroxyaniline Oxidation - N-oxidation Aniline [3]
MR005148 Aniline 2-aminophenol Oxidation - Hydrolyzationn Phenazopyridine [4], [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009056 4-chloro aniline 4-amino phenol Unclear - Unclear BMS-986205 [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005147 4-aminophenol N-acetyl-4-Aminophenol Conjugation - Acetylation Phenazopyridine [4], [5], [6]
References
1 Aniline and its metabolites generate free radicals in yeast
2 Human metabolism and excretion kinetics of aniline after a single oral dose
3 Aniline derivative-induced methemoglobin in rats
4 Metabolism and disposition of phenazopyridine in rat
5 The metabolism and excretion of phenazopyridine hydrochloride in animals and man
6 Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs
7 Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program

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