Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005147)
Formula
SVG example
Acetylation
Reactant 4-aminophenol Product N-acetyl-4-Aminophenol
Reactant Info Product Info
Metabolic Type Conjugation - Acetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012856 Aniline 4-aminophenol Oxidation - Aromatic hydroxylation Aniline [1]
MR009056 4-chloro aniline 4-amino phenol Unclear - Unclear BMS-986205 [2]
MR005146 Aniline 4-aminophenol Oxidation - Hydrolyzationn Phenazopyridine [3], [4], [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007295 BCP-13498 Paracetamol Unclear BCP-13498 [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007297 Paracetamol Glucuronidation of paracetamol Conjugation - Glucuronidation BCP-13498 [7]
MR007296 Paracetamol N-acetil-p-benzoquinone imine Unclear BCP-13498 [8]
MR007298 Paracetamol Unclear Unclear BCP-13498 [9]
MR014085 Paracetamol Unclear Unclear BCP-13498 [10]
References
1 Aniline and its metabolites generate free radicals in yeast
2 Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program
3 Metabolism and disposition of phenazopyridine in rat
4 The metabolism and excretion of phenazopyridine hydrochloride in animals and man
5 Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs
6 DrugBank(Pharmacology-Metabolism):BCP-13498
7 Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Biochem Pharmacol. 1993 May 5;45(9):1809-14.
8 Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400.
9 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
10 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.

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