Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005403)
Formula Reactant PF-04965842 Product Abrocitinib M5 metabolite
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005393 PF-04965842 Abrocitinib M1 metabolite Oxidation - Oxidationn PF-04965842 [1]
MR005397 PF-04965842 Abrocitinib M2 metabolite Unclear PF-04965842 [2]
MR005400 PF-04965842 Abrocitinib M3 metabolite Unclear PF-04965842 [2]
MR005388 PF-04965842 Abrocitinib M4 metabolite Oxidation - Oxidationn PF-04965842 [1]
MR012168 PF-04965842 PF-04965842 Metabolites M1 Unclear - Unclear PF-04965842 [2]
MR012178 PF-04965842 PF-04965842 Metabolites M2 Unclear - Unclear PF-04965842 [3]
MR012181 PF-04965842 PF-04965842 Metabolites M3 Unclear - Unclear PF-04965842 [3]
MR012173 PF-04965842 PF-04965842 Metabolites M4 Unclear - Unclear PF-04965842 [3]
MR012184 PF-04965842 PF-04965842 Metabolites M5 Unclear - Unclear PF-04965842 [3]
References
1 Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma
2 The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
3 Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men

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