Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012181)
Formula Reactant PF-04965842 Product PF-04965842 Metabolites M3
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005393 PF-04965842 Abrocitinib M1 metabolite Oxidation - Oxidationn PF-04965842 [1]
MR005397 PF-04965842 Abrocitinib M2 metabolite Unclear PF-04965842 [2]
MR005400 PF-04965842 Abrocitinib M3 metabolite Unclear PF-04965842 [2]
MR005388 PF-04965842 Abrocitinib M4 metabolite Oxidation - Oxidationn PF-04965842 [1]
MR005403 PF-04965842 Abrocitinib M5 metabolite Unclear PF-04965842 [2]
MR012168 PF-04965842 PF-04965842 Metabolites M1 Unclear - Unclear PF-04965842 [2]
MR012178 PF-04965842 PF-04965842 Metabolites M2 Unclear - Unclear PF-04965842 [3]
MR012173 PF-04965842 PF-04965842 Metabolites M4 Unclear - Unclear PF-04965842 [3]
MR012184 PF-04965842 PF-04965842 Metabolites M5 Unclear - Unclear PF-04965842 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012183 PF-04965842 Metabolites M3 PF-04965842 m/z 340-5 Unclear - Unclear PF-04965842 [3]
MR012182 PF-04965842 Metabolites M3 PF-04965842 m/z 356-1a Unclear - Unclear PF-04965842 [3]
References
1 Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma
2 The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
3 Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men

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