Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005421)
Formula
UGT2B7 ...
SVG example
Glucuronidation
Reactant ABL001 Product Asciminib metabolite M30.5
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011635 ABL001 ABL001 Metabolite M45 Unclear - Unclear ABL001 [1]
MR011633 ABL001 ABL001 Metabolite M8 Hydrolysis - Hydrolysis ABL001 [1]
MR005419 ABL001 Asciminib metabolite M10 Oxidation - O-dealkylation ABL001 [1]
MR005426 ABL001 Asciminib metabolite M27.5 Conjugation - Glucuronidation ABL001 [1]
MR005424 ABL001 Asciminib metabolite M29.5 Oxidation - Oxidationn ring opening ABL001 [1]
MR005416 ABL001 Asciminib metabolite M37 Oxidation - Oxidationn ring opening ABL001 [1]
MR005425 ABL001 Asciminib metabolite M39 Oxidation - Oxidationn ring opening ABL001 [1]
MR005423 ABL001 Asciminib metabolite M44 Oxidation - Oxidationn ABL001 [1]
References
1 Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects

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