Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005643)
Formula
CYP3A4 ...
SVG example
O-demethylation
Reactant N-Desmethylvenlafaxine Product N,O-Didesmethylvenlafaxine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005642 Venlafaxine hydrochloride N-Desmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008963 Desvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - N-demethylation Desvenlafaxine [4]
MR000772 Desvenlafaxine succinate N,O-Didesmethylvenlafaxine Oxidation - N-Demethylation Desvenlafaxine succinate [5]
MR005638 Desvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [1], [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005640 N,O-Didesmethylvenlafaxine N,N,O-tridesmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [1], [2], [3]
MR005639 N,O-Didesmethylvenlafaxine N,O-didesmethylvenlafaxine glucuronide Conjugation - Glucuronidation Venlafaxine hydrochloride [1], [2], [3]
References
1 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
2 Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br J Clin Pharmacol. 1996 Feb;41(2):149-56.
3 Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers
4 DrugBank(Pharmacology-Metabolism):Desvenlafaxine
5 DrugBank(Pharmacology-Metabolism)Desvenlafaxine succinate

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.