Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008963)
Formula Reactant Desvenlafaxine Product N,O-Didesmethylvenlafaxine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008964 Desvenlafaxine Benzyl hydroxy desvenlafaxine Oxidation - Hydroxylation Desvenlafaxine [1]
MR008965 Desvenlafaxine Cyclohexane ring hydroxy desvenlafaxine Oxidation - Hydroxylation Desvenlafaxine [1]
MR008967 Desvenlafaxine Desvenlafaxine N-oxide Oxidation - N-oxidation Desvenlafaxine [1]
MR008966 Desvenlafaxine Desvenlafaxine O-glucuronide Conjugation - O-glucuronidation Desvenlafaxine [1]
MR005641 Desvenlafaxine O-Desmethylvenlafaxine glucuronide Conjugation - Glucuronidation Venlafaxine hydrochloride [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000772 Desvenlafaxine succinate N,O-Didesmethylvenlafaxine Oxidation - N-Demethylation Desvenlafaxine succinate [5]
MR005643 N-Desmethylvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - O-demethylation Venlafaxine hydrochloride [2], [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005640 N,O-Didesmethylvenlafaxine N,N,O-tridesmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [2], [3], [4]
MR005639 N,O-Didesmethylvenlafaxine N,O-didesmethylvenlafaxine glucuronide Conjugation - Glucuronidation Venlafaxine hydrochloride [2], [3], [4]
References
1 DrugBank(Pharmacology-Metabolism):Desvenlafaxine
2 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
3 Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br J Clin Pharmacol. 1996 Feb;41(2):149-56.
4 Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers
5 DrugBank(Pharmacology-Metabolism)Desvenlafaxine succinate

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