Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005676)
Formula
CYP3A4 ...
SVG example
Reduction
Reactant Zidovudine Product 3'-Aminothymidine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005678 Zidovudine 3'-azido-3'-deoxy-5'- O-beta-D-glucopyranuronosylthymidine Conjugation - Glucuronidation Zidovudine [1], [2]
MR005679 Zidovudine 5'glucuronyl zidovudine Unclear Zidovudine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005677 3'-Aminothymidine 3'-amino-3'-deoxythimidine glucuronide metabolite Conjugation - Glucuronidation Zidovudine [1], [2]
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis
3 DrugBank(Pharmacology-Metabolism):Zidovudine

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