Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005678)
Formula
SVG example
Glucuronidation
Reactant Zidovudine Product 3'-azido-3'-deoxy-5'- O-beta-D-glucopyranuronosylthymidine
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005676 Zidovudine 3'-Aminothymidine Reduction - Reduction Zidovudine [1], [2]
MR005679 Zidovudine 5'glucuronyl zidovudine Unclear Zidovudine [3]
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis
3 DrugBank(Pharmacology-Metabolism):Zidovudine

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