Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005923)
Formula Reactant CBL-954 Product The hydroxylamine metabolite
Reactant Info Product Info
Metabolic Enzyme Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005921 CBL-954 2-NHOH Unclear CBL-954 [1]
MR005922 CBL-954 4-NHOH Unclear CBL-954 [1]
References
1 uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954

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