Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006038)
Formula
SVG example
Hydrolyzationn
Reactant Bendamustine Product -hydroxybendamustine (Bendamustine metabolite M3)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006040 Bendamustine Beta-hydroxybendamustine Unclear Bendamustine [1]
MR006036 Bendamustine Monohydroxy-bendamustine (bendamustine metabolite HP1) Hydrolysis - Hydrolysis Bendamustine [2]
MR006039 Bendamustine N-desmethyl-bendamustine (Bendamustine metabolite M4) Oxidation - Dealkylation Bendamustine [2]
References
1 Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine
2 Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54.

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