Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006143)
Formula Reactant NOVA-63035 Product 11-dehydrodexamethasone
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006145 NOVA-63035 6alpha-Hydroxydexamethasone Oxidation - Aliphatic hydroxylation NOVA-63035 [1]
MR006146 NOVA-63035 6beta-Hydroxydexamethasone Oxidation - Aliphatic hydroxylation NOVA-63035 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000790 Dexamethasone sodium phosphate 11-dehydrodexamethasone Reduction - Reduction Dexamethasone sodium phosphate [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000789 11-dehydrodexamethasone Dexamethasone Unclear Dexamethasone sodium phosphate [2], [3]
MR006144 11-dehydrodexamethasone Dexamethasone Reduction - Reduction NOVA-63035 [2]
References
1 Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation
2 Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
3 Metabolism of synthetic corticosteroids by 11 beta-hydroxysteroid-dehydrogenases in man Steroids. 1998 May-Jun;63(5-6):271-7. doi: 10.1016/s0039-128x(98)00039-7.

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