Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006144)
Formula Reactant 11-dehydrodexamethasone Product Dexamethasone
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000790 Dexamethasone sodium phosphate 11-dehydrodexamethasone Reduction - Reduction Dexamethasone sodium phosphate [1], [2]
MR006143 NOVA-63035 11-dehydrodexamethasone Reduction - Reduction NOVA-63035 [1]
References
1 Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
2 Metabolism of synthetic corticosteroids by 11 beta-hydroxysteroid-dehydrogenases in man Steroids. 1998 May-Jun;63(5-6):271-7. doi: 10.1016/s0039-128x(98)00039-7.

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