Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006192)
Formula Reactant Tienilic acid Product Thiophene-4,5-epoxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Epoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006193 Tienilic acid 5-Hydroxy-tienilic Acid Oxidation - Hydrolyzationn Tienilic acid [1], [2]
MR006190 Tienilic acid Ticrynafen S-oxide Oxidation - Oxidationn Tienilic acid [3]
MR006191 Tienilic acid Tienilic acid-s-oxide Oxidation - S-oxidation Tienilic acid [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002305 Suprofen Thiophene-4,5-epoxide Unclear Suprofen [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002299 Thiophene-4,5-epoxide Suprofen metabolite M1 Intermediate Unclear Suprofen [3]
MR002300 Thiophene-4,5-epoxide Suprofen metabolite M2 Unclear Suprofen [3]
MR002301 Thiophene-4,5-epoxide Suprofen metabolite M3 Unclear Suprofen [3]
MR002302 Thiophene-4,5-epoxide Suprofen metabolite M4 Unclear Suprofen [3]
References
1 Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation
2 Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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