Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006382)
Formula
CYP4A11 ...
SVG example
Reactant NSC-122758 Product 5,6-Epoxyretinoic acid
Reactant Info Product Info
Metabolic Enzyme Lauric acid omega-hydroxylase (CYP4A11) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [1]
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [1]
MR006381 NSC-122758 All-trans-18-Hydroxyretinoic acid Oxidation - Hydrolyzationn NSC-122758 [1], [2]
MR006384 NSC-122758 Retinoyl b-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
MR006385 NSC-122758 Retinyl beta-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009629 Tretinoin 5,6-epoxy-RA Oxidation - Ring epoxidation Tretinoin [3], [3], [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009630 5,6-epoxy-RA Rac-5,6-Epoxy-retinoyl-beta-D-glucuronide Conjugation - Glucuronidation Tretinoin [4]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.
3 Retinoic acid metabolism and mechanism of action: a review
4 Clinical pharmacokinetics of tretinoin

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