Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006383)
Formula
CYP3A7 ...
SVG example
Reactant NSC-122758 Product 4-Oxoretinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [1]
MR006382 NSC-122758 5,6-Epoxyretinoic acid Unclear NSC-122758 [1]
MR006381 NSC-122758 All-trans-18-Hydroxyretinoic acid Oxidation - Hydrolyzationn NSC-122758 [1], [2]
MR006384 NSC-122758 Retinoyl b-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
MR006385 NSC-122758 Retinyl beta-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009627 4-Hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [1], [3]
MR001259 4-hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Isotretinoin [4]
MR001255 4-oxo-13-cis-retinoic acid 4-Oxoretinoic acid Unclear Isotretinoin [4]
MR005732 Retinoic acid 4-Oxoretinoic acid Unclear Beta carotene [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009628 4-Oxoretinoic acid 4-Oxoretinoic acid glucuronide Conjugation - Glucuronidation Tretinoin [6]
MR001260 4-Oxoretinoic acid 4-oxo-13-cis-retinoic acid Other reaction - Trans-Cis Isomerization Isotretinoin [4]
MR005733 4-Oxoretinoic acid 4-oxo-retinoyl glucuronide Conjugation - Glucuronidation Beta carotene [5]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.
3 Retinoic acid metabolism and mechanism of action: a review
4 DrugBank(Pharmacology-Metabolism)Isotretinoin
5 #NAME?
6 Clinical pharmacokinetics of tretinoin

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