Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006396)
Formula
CYP2C19 ...
SVG example
Reactant Hydroxytriptolide Product Trihydroxytriptolide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006395 PG-490 Hydroxytriptolide Oxidation - Hydrolyzationn PG-490 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006398 Hydroxytriptolide Hydroxytriptolide glucuronoside Conjugation - Conjugation PG-490 [1]
MR006399 Hydroxytriptolide Hydroxytriptolide glutathione Conjugation - Conjugation PG-490 [1]
MR006400 Hydroxytriptolide Hydroxytriptolide sulfate Conjugation - Conjugation PG-490 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006397 Trihydroxytriptolide Dehydrotrihydroxytriptolide Unclear PG-490 [1]
References
1 Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.

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