Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006449)
Formula
SVG example
N3-demethylation
Reactant SC-15090 Product 3-MX
Reactant Info Product Info
Metabolic Type Oxidation - N3-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006451 SC-15090 3,7-DAU Oxidation - 3-O-demethylation SC-15090 [1]
MR006450 SC-15090 3,7-DMU Oxidation - N7-demethylation SC-15090 [2]
MR006447 SC-15090 7-MX Oxidation - N7-demethylation SC-15090 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001875 Oxtriphylline 3-Methylxanthine Unclear Oxtriphylline [3]
MR004946 Theophylline 3-methylxanthine Oxidation - 1-N-demethylation Theophylline [4]
References
1 Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors. J Clin Pharmacol. 2009 Jan;49(1):17-29.
2 Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305.
3 Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma Clin Pharmacol Ther. 2003 May;73(5):468-74. doi: 10.1016/s0009-9236(03)00013-4.
4 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.