Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006450)
Formula
SVG example
N7-demethylation
Reactant SC-15090 Product 3,7-DMU
Reactant Info Product Info
Metabolic Type Oxidation - N7-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006451 SC-15090 3,7-DAU Oxidation - 3-O-demethylation SC-15090 [1]
MR006449 SC-15090 3-MX Oxidation - N3-demethylation SC-15090 [2]
MR006447 SC-15090 7-MX Oxidation - N7-demethylation SC-15090 [2]
References
1 Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors. J Clin Pharmacol. 2009 Jan;49(1):17-29.
2 Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305.

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