Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR006588)
Formula
	Reactant	Clonidine		Product	2,6-dichlorophenylguanidine
	Reactant	Reactant Info		Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006589	Clonidine	4,5-dehydroclonidine	Unclear	Clonidine	[1]
MR006587	Clonidine	4-Hydroxyclonidine	Oxidation - 4-hydroxylation	Clonidine	[2]
MR006590	Clonidine	4-oxoclonidine	Unclear	Clonidine	[1]

References
1	The metabolism of N,N'-dimethylclonidine by rat liver microsomes [proceedings]
2	CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.

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