Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006598)
Formula
SVG example
Oxidationn
Reactant Hydroxy-dabrafenib Product Carboxy-dabrafenib
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006597 Dabrafenib mesylate Hydroxy-dabrafenib Oxidation - Aliphatic hydroxylation Dabrafenib mesylate [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006599 Carboxy-dabrafenib Desmethyl-dabrafenib Oxidation - Decarboxylation Dabrafenib mesylate [1]
References
1 Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation
2 Clinical Pharmacokinetics and Pharmacodynamics of Dabrafenib
3 Prediction of the Transporter-Mediated Drug-Drug Interaction Potential of Dabrafenib and Its Major Circulating Metabolites

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.