Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006599)
Formula
SVG example
Decarboxylation
Reactant Carboxy-dabrafenib Product Desmethyl-dabrafenib
Reactant Info Product Info
Metabolic Type Oxidation - Decarboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006598 Hydroxy-dabrafenib Carboxy-dabrafenib Oxidation - Oxidationn Dabrafenib mesylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006600 Desmethyl-dabrafenib M30-Dabrafenib Oxidation - Oxidationn Dabrafenib mesylate [1]
MR006601 Desmethyl-dabrafenib M31-Dabrafenib Oxidation - Oxidationn Dabrafenib mesylate [1]
References
1 Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation

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