Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006715)
Formula
CYP2C9 ...
SVG example
Hydrolyzationn
Reactant Duloxetine hydrochloride Product 5-hydroxy duloxetine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006722 Duloxetine hydrochloride 4-hydroxy duloxetine Oxidation - Hydrolyzationn Duloxetine hydrochloride [1]
MR006720 Duloxetine hydrochloride 6-hydroxy duloxetine Oxidation - Hydrolyzationn Duloxetine hydrochloride [1]
MR006726 Duloxetine hydrochloride Dihydrodiol duloxetine Unclear Duloxetine hydrochloride [2]
MR006725 Duloxetine hydrochloride N-desmethyl duloxetine Unclear Duloxetine hydrochloride [2]
MR006724 Duloxetine hydrochloride Thinel alcohol+Naphthol Unclear Duloxetine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006716 5-hydroxy duloxetine Catechol duloxetine Oxidation - Hydrolyzationn Duloxetine hydrochloride [3]
References
1 Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94.
2 Metabolism, excretion, and pharmacokinetics of duloxetine in healthy human subjects
3 DrugBank(Pharmacology-Metabolism):Duloxetine

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