Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006776)
Formula Reactant 4-Hydroxy tolbutamide Product 1-butyl-3-(p-formylphenyl)sulphonylurea
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006775 Tolbutamide 4-Hydroxy tolbutamide Oxidation - Hydrolyzationn Tolbutamide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006778 4-Hydroxy tolbutamide 4-Carboxytolbutamide Unclear Tolbutamide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006777 1-butyl-3-(p-formylphenyl)sulphonylurea 1-butyl-3-(p-carboxyphenyl)sulphonylurea Oxidation - Oxidationn Tolbutamide [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes
3 A new aspect of tolbutamide metabolism in the rabbit: the role of 1-butyl-3-(p-formylphenyl)sulphonylurea

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