Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006920)
Formula Reactant HydroxylLoteprednol Product 1-cortienic acid (PJ-90)
Reactant Info Product Info
Metabolic Enzyme Serum paraoxonase/arylesterase 1 (PON1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006919 Loteprednol etabonate HydroxylLoteprednol Hydrolysis - Hydrolysis Loteprednol etabonate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006918 1-cortienic acid etabonate (PJ-91) 1-cortienic acid (PJ-90) Hydrolysis - Hydrolysis Loteprednol etabonate [1]
References
1 Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.

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