Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006924)
Formula Reactant beta-hydroxy acid of lovastatin Product 6'-Exomethylene lovastatin
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006921 Lovastatin beta-hydroxy acid of lovastatin Hydrolysis - Hydrolysis Lovastatin [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006923 beta-hydroxy acid of lovastatin 3''-Hydroxylovastatin Unclear Lovastatin [1]
MR006922 beta-hydroxy acid of lovastatin 6'-beta-Hydroxylovastatin Oxidation - Hydrolyzationn Lovastatin [3]
References
1 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
2 Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
3 Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.

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