Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006933)
Formula
SVG example
Reactant Lurasidone Product ID-11614
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006930 Lurasidone ID-14326 Unclear Lurasidone [1]
MR006931 Lurasidone ID-20219 Unclear Lurasidone [1]
MR006932 Lurasidone ID-20220 Unclear Lurasidone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013365 M-813 ID-11614 Unclear M-813 [2]
MR011693 TIOSPIRONE Benzisothiazol-3-yl-piperazin (BITP) Unclear - Unclear TIOSPIRONE [3]
MR005684 Ziprasidone 3-(piperazine-1-yl)-1,2-benzisothiazole Oxidation - Oxidationn N-dealkylation Ziprasidone [4]
MR013364 M-813 Metabolite MX1 ID-11614 Unclear M-813 [5]
MR013357 M-813 Metabolite MX11 ID-11614 Unclear M-813 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005685 3-(piperazine-1-yl)-1,2-benzisothiazole 3-(piperazine-1-yl)-1,2-benzisothiazole sulfoxide Oxidation - Oxidationn Ziprasidone [4]
MR011694 Benzisothiazol-3-yl-piperazin (BITP) BITP-O(BMY-40729) Unclear - Unclear TIOSPIRONE [3]
MR013358 ID-11614 ID15002 Unclear M-813 [5]
References
1 Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503.
2 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
3 Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry
4 Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans
5 In vitro metabolism of perospirone in rat, monkey and human liver microsomes

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