Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013357)
Formula Reactant M-813 Metabolite MX11 Product ID-11614
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013356 Hydroxyperospirone M-813 Metabolite MX11 Unclear M-813 [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013360 M-813 Metabolite MX11 M-813 Metabolite MX9 Unclear M-813 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006933 Lurasidone ID-11614 Unclear Lurasidone [3]
MR013365 M-813 ID-11614 Unclear M-813 [1]
MR011693 TIOSPIRONE Benzisothiazol-3-yl-piperazin (BITP) Unclear - Unclear TIOSPIRONE [4]
MR005684 Ziprasidone 3-(piperazine-1-yl)-1,2-benzisothiazole Oxidation - Oxidationn N-dealkylation Ziprasidone [5]
MR013364 M-813 Metabolite MX1 ID-11614 Unclear M-813 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005685 3-(piperazine-1-yl)-1,2-benzisothiazole 3-(piperazine-1-yl)-1,2-benzisothiazole sulfoxide Oxidation - Oxidationn Ziprasidone [5]
MR011694 Benzisothiazol-3-yl-piperazin (BITP) BITP-O(BMY-40729) Unclear - Unclear TIOSPIRONE [4]
MR013358 ID-11614 ID15002 Unclear M-813 [2]
References
1 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
2 In vitro metabolism of perospirone in rat, monkey and human liver microsomes
3 Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503.
4 Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry
5 Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans

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