Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007032)
Formula
SVG example
Glucuronidation
Reactant Hesperetin Product Hesperetin 7-O-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007030 Hesperetin Eriodictyol Oxidation - 4'-demethylation Hesperetin [1]
MR007031 Hesperetin Hesperetin 3p-O-Glucuronide Conjugation - Glucuronidation Hesperetin [2], [3]
MR004485 Hesperetin 3-(3'-Hydroxy-4'-methoxyphenyl)-2-propionic acid Unclear VS-12343 [4]
MR003858 Hesperetin Hesperetin-sulfo-O-glucuronide Unclear BRN-0183227 [5]
References
1 DrugBank(Pharmacology-Metabolism):Hesperetin
2 BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
3 Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation
4 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
5 Stratification of Volunteers According to Flavanone Metabolite Excretion and Phase II Metabolism Profile after Single Doses of 'Pera' Orange and 'Moro' Blood Orange Juices

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